Beyond the Symptom: The Biology of Fatigue

Monday, September 27, 2021

Date: September 27-28, 2021
Location: Virtual Workshop

Beyond the Symptom: The Biology of Fatigue took place on September 27-28, 2021. This was a joint workshop organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program, with support from the Blueprint Neuroscience Research Program. The workshop was held via Zoom webinar from 10:00 am to 6:00 pm Eastern time on both days.

Please visit Beyond the Symptom: The Biology of Fatigue for more information about the workshop.

Workshop recordings:

Presentations:

Day 1: Session 1	Fatigue in Acute to Chronic Disease (Josh Fessel)(pdf, 1067 KB) The Role of Temperature in Athletic Fatigue (H. Craig Heller)(pdf, 2451 KB) 'Fatigue' in Myalgic Encephalomyelitis (Betsy Keller, Candace Receno)(pdf, 3421 KB) Fatigue in Autoimmune Disorders (Lauren Krupp)(pdf, 2442 KB) Fatigue in Neurological Disorders: The Sensory Attenuation Hypothesis (Anna Kuppuswamy)(pdf, 3365 KB) Cancer and Cancer Treatment Fatigue (Christine Miaskowski)(pdf, 695 KB) Fatigue in the Setting of Disease Sleep Disruption (Phyllis C. Zee)(pdf, 5005 KB)
Day 1: Session 2	Gut-Brain Axis (Gerard Clarke)(pdf, 3401 KB) Immune System Dysfunction as a Cause of Fatigue (Mark M. Davis)(pdf, 3225 KB) Central Hypothesis for ME/CFS (Ronald Davis)(pdf, 1094 KB) Circadian Rhythms and Fatigue (Elizabeth B. Klerman)(pdf, 2382 KB) ME/CFS (H. Ian Lipkin)(pdf, 2331 KB) Neuron-glia Metabolic Coupling Mediated by Lactate: Role in Plasticity and Pathology (Pierre J. Magistretti)(pdf, 3016 KB) Inflammation Effects on the Brain and Behavior: Relevance to Fatigue (Andrew H. Miller)(pdf, 1539 KB) Immune Dysfunction in ME/CFS (Maureen Hanson)(pdf, 2859 KB) Immunomodulators as Regulators of Sleep and Fatigue (Mark R. Opp)(pdf, 1143 KB) Sleep Loss, Gut, and Oxidative Stress (Dragana Rogulja)(pdf, 2246 KB) Brain-Immune Axis in Fatigue (Asya Rolls)(pdf, 4019 KB)
Day 2: Opening Session	Mechanisms of Fatigue in Health and Disease (Walter Koroshetz)(pdf, 1981 KB)
Day 2: Session 3	Approaches to Study the Biology of Fatigue in Preclinical Models: How we Study Cancer-related Fatigue in Mice (Robert Dantzer)(pdf, 1806 KB) Studying Hibernation Biology to Gain Insights into Fatigue (Kelly L. Drew)(pdf, 3626 KB) Using LPS to Model Fatigue (Julie Lasselin)(pdf, 2617 KB) Electroencephalography of non-refreshing sleep (Janet M. Mullington)(pdf, 2746 KB) Invertebrates to study fatigue (David Raizen)(pdf, 1298 KB) Use of EHR for Understanding disease (Marilyn D. Ritchie)(pdf, 4616 KB) Pharmacological Studies of Effort-related Motivational Function in Rodents: Relation to Fatigue/Anergia/Avolition (John D. Salamone)(pdf, 2071 KB) GWAS of Fatigue: Use of the UK Biobank for Genetic Discovery (Richa Saxena)(pdf, 4098 KB) The Biology of Fatigue: Omics in Human Disease (Ronald G. Tompkins)(pdf, 1725 KB)
Day 2: Session 4	The Role of the Brainstem in Slow-Wave-Sleep Control (Christelle Anaclet)(pdf, 3504 KB) Psychomotor Slowing (Hugo Critchley)(pdf, 2751 KB) Fatigue: A Hypothalamic Basis (Patrick M. Fuller)(pdf, 2744 KB) Neural and Fluid Dynamics of Sleep (Laura Lewis)(pdf, 1531 KB) The Glymphatic System (Maiken Nedergaard)(pdf, 8214 KB) Evidence for a Network of Fatigue-Related Areas in the Brain (Glenn Wylie)(pdf, 2219 KB) Neuroimaging: PET, fMRI, MRS (Jarred Younger)(pdf, 2591 KB)