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Minority Biomedical Research Support


Multicomponent Application

Mechanistic Study

A mechanistic study is designed to understand a biological or behavioral process, the pathophysiology of a disease, or the mechanism of action of an intervention.


National Library of Medicine's database for scientific publications.

metabolic diseases

Diseases or disorders that disrupt normal metabolism, or the process of converting food into energy on a basic cellular level.


A purchase of supplies or services using simplified acquisition procedures, the aggregate amount of which does not exceed the micro-purchase threshold.

Minor A&R

An A&R project under a grant whose primary purpose is other than construction or modernization, including a project involving improvement or remodeling, which does not exceed $500,000 in direct costs. Minor A&R is not an allowable activity or cost under grants to individuals or grants for limited purposes, such as grants in support of scientific meetings (conference grants). Routine maintenance and repair of the organization's physical plant or its equipment is not considered A&R; these types of costs are typically treated as F&A costs.

Minority Access to Research Careers (MARC)

The Minority Access to Research Careers (MARC) Branch of the National Institute of General Medical Sciences (NIGMS) provides research training opportunities for students and faculty from minority groups underrepresented in the biomedical and behavioral sciences relevant to biomedicine, including mathematics and engineering.

Minority Biomedical Research Support (MBRS)

A program to strengthen the biomedical research and research training capability of ethnic minority institutions. The intent is to increase the involvement of minority faculty and students in biomedical research.

Model Organism

Animal, plant, or other organism used to study basic biologic processes to provide insight into other organisms. See Model Organism Sharing.

Model Organism Sharing

Policy stating a PD/PI applicant must submit plans for sharing mammalian and non-mammalian eukaryotic models to comply with the NIH Policy on Sharing of Model Organisms. Go to NIH's Model Organisms for Biomedical Research.


Alteration, renovation, remodeling, improvement, and/or repair of an existing building and the provision of equipment necessary to make the building suitable for use for the purposes of a particular program. The entire purpose of the modernization grant is to modernize biomedical research facilities. A modernization grant cannot support the conduct of any research.

Modified Summary Statement

Former term for a summary statement containing reviewer critiques, which is now standard practice. See Summary Statement.

Modified Total Direct Cost (MTDC)

Modified Total Direct Cost (MTDC) means all direct salaries and wages, applicable fringe benefits, materials and supplies, services, travel, and up to the first $25,000 of each subaward (regardless of the period of performance of the subawards under the award). MTDC excludes equipment, capital expenditures, charges for patient care, rental costs, tuition remission, scholarships and fellowships, participant support costs and the portion of each subaward in excess of $25,000. Other items may only be excluded when necessary to avoid a serious inequity in the distribution of indirect costs, and with the approval of the cognizant agency for indirect costs.

Modular Application

A type of grant application in which support is requested in specified increments without the need for detailed supporting information related to separate budget categories. When modular procedures apply, they affect not only application preparation but also review, award, and post-award administration. Go to Modular.


The smallest particle of a substance that has all of the physical and chemical properties of that substance. Molecules are made up of one or more atoms. If they contain more than one atom, the atoms can be the same (an oxygen molecule has two oxygen atoms) or different (a water molecule has two hydrogen atoms and one oxygen atom). Biological molecules, such as proteins and DNA, can be made up of many thousands of atoms.


A process whereby the programmatic and business management performance aspects of a grant are assessed by reviewing information gathered from various required reports, audits, site visits, and other sources.


Memorandum of Understanding


Medical Scientist Training Program - MTSP supports the integrated medical (or equivalent professional clinical) degree and graduate research training required for the investigation of human diseases

Multi-project Grant Application

A multi-project application is a single grant application submission with multiple, interrelated components with defined work, personnel, sites and budgets that share a common focus or objective.


Multi-year funded (MYF) awards are where the project period and budget period are the same and are longer than one year.
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Form Approved OMB# 0925-0648 Exp. Date 05/31/2021