Researchers participating in the Blueprint Neurotherapeutics Network receive grant funding (a UG3/UH3 award, or a U44 award if a small business) and no-cost access to drug development consultants and contract research organizations (CROs).
Research Grants (UG3/UH3 or U44)
All projects that enter the BPN will begin with a preparatory phase of up to one year, which should be used to complete any studies required to initiate Discovery or Development activities and to engage the LDT in establishing a detailed research plan and go/no-go milestones for all subsequent work.
Projects can enter the BPN during the Discovery or Development stage and may seek support through phase I/first-in-human testing. Discovery involves iterative medicinal chemistry to improve the potency and ADMET properties of compounds in order to identify a development candidate. During Development, a development candidate undergoes preclinical toxicology testing required for an IND and manufacturing, ultimately advancing into phase I/first-in-human testing. BPN-supported Development activities include chemical manufacturing and controls (CMC), formulation development, toxicology studies, regulatory support, and phase I/first-in-human testing.
Charles Cywin, PhD
Health Program Specialist
Carolyn Bondar, PhD
Rakonda Medley, BS