Other NIH Programs for Translational Neuroscience

Funding for High Throughput Screening

Solicitation of Assays for HTS to Discover Chemical Probes

Funding for Medicinal Chemistry (Hit-to-Lead)

Solicitation of Validated Hits for the Discovery of in vivo Chemical Probes

Funding for Preclinical Proof-of-Concept

Drug Discovery for Nervous System Disorders

Funding for Preclinical/Clinical Development

National Cooperative Drug Discovery/Development Groups (NCDDG)

  • Support: Up to 5 years of funding for multidisciplinary teams, Public Private Partnerships
  • Participating Institutes: NIMH, NIAAA, NIDA
  • To apply: PAR-17-185 (U01), PAR-17-186 (U19)

Regulatory Affairs Assistance for Medications Development

  • Support: Provides consultation and advice on regulatory requirements
  • Participating Institute: NIDA
  • To apply: Contact Robert Walsh, R.A.C.

Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (STTR)

  • Support: Up to 2 years for Phase I and up to 3 years for Phase II may be requested. Budgets up to $1.0M total costs per year for Phase I and up to $1.5 total costs per year for Phase II may be requested.

  • Participating Institute: NIAAA

  • To apply: PAR-18-580 (UT2 - Clinical Trial Optional)

Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use disorder and Alcohol-related disorders (SBIR)

  • Support: Up to 2 years for Phase I and up to 3 years for Phase II may be requested. Budgets up to $1.0M total costs per year for Phase I and up to $1.5 total costs per year for Phase II may be requested.

  • Participating Institute: NIAAA
  • To apply: PAR-18-578 (U44 - Clinical Trial Optional)

Strategic Alliances for Medications Development to Treat Substance-Use Disorders

  • Support: Up to 3 years of funding, includes discovery, development, and clinical trials. $3M per year with expectation of matching funds

  • Participating Institute: NIDA

  • To apply: PAR-18-218 (R01)

Grand Opportunities in Medications Development for Substance-Use Disorders

  • Support: Up to 3 years of funding, milestone-driven, up to $5M per year

  • Participating Institute: NIDA

  • To apply: PAR-18-219 (U01)

Alzheimer's Drug-Development Program

  • Support: Up to 5 years of funding, milestone-driven, up to $1M per year

  • Participating Institute: NIA

  • To apply: PAR-18-174 (U01)

Services

Services Services for Pharmacology

Epilepsy Therapy Screening Program (ETSP)

  • Support: Screens compounds in animal seizure models
  • To apply: Contact John Kehne, Ph.D.

Addiction Treatment Discovery Program (ATDP)

  • Support: Screens compounds in animal models of addiction
  • To apply: Contact David White, Ph.D., (301) 443-8889

NIMH Psychoactive Drug Screening Program (PDSP)

  • Support: Screens novel psychoactive compounds for pharmacological and functional activity at cloned human or rodent CNS receptors, channels, and transporters.
  • To apply: Contact Jamie Driscoll, (301) 443-5288

Services for Toxicology

Bridging Interventional Development Gaps (BrIDGs)

NIMH Toxicological Evaluation of Novel Ligands Program

  • Support: Provides toxicology, safety, in vitro ADME, and pharmacokinetic assessment of promising, target-selective compounds for use as imaging ligands and novel psychoactive drugs.
  • To apply: Contact Jamie Driscoll, (301) 443-5288

NIDA Toxicology Program

  • Support: Provides IND-directed toxicology services for substance abuse indications.
  • To apply: Contact Nathan M. Appel, Ph.D., (301) 443-8475

Services for Chemistry

Bridging Interventional Development Gaps (BrIDGs)

NIDA Drug Supply Program

  • Support: Provides chemicals and research probes that are either unavailable, difficult to obtain, or very expensive to buy to researchers, including marijuana plant materials, cannabinoids, opioids, stimulants, sedatives, hypnotics, standardized research E-Cigarettes and nicotine research c, etc. Also provides analytical services for the analysis of researchers’ experimental samples.
  • To apply: Contact: Richard Kline, Ph.D., (301) 443-5280

NIMH Chemical Synthesis and Drug Supply Program

  • Support: Synthesizes and distributes novel research chemicals, psychoactive drugs, and compounds unavailable from commercial sources. Also supports radiosynthesis, medicinal chemistry, and GMP synthesis for clinical studies.
  • To apply: Contact Jamie Driscoll, (301) 443-5288

NIDA Chemistry and Pharmaceutics Branch

  • Support: Medicinal chemistry, analytical chemistry, metabolism, pharmacokinetics and pharmacodynamics, pharmacogenetics and pharmaceutics/formulation development aimed at the design, evaluation and development of medications for the treatment of drug addiction
  • To apply: Contact Rik Klein, (301)-827-5243, rkline@nida.nih.gov