Chronic pain is a major public health problem, and treatments are limited. More research is needed to fully understand how acute pain evolves into chronic pain, who will develop chronic pain, and how to develop better treatments to prevent the transition.
The NIH Pain Consortium, a collaboration of 25 Institutes, Centers, and Offices from across NIH, developed and presented a proposal to support a series of Funding Opportunity Announcements (FOAs) to address the need for additional research on the transition from acute to chronic neuropathic pain. The proposal’s objectives were based on recommendations provided by outside experts during a workshop hosted by the NIH.
The Blueprint Grand Challenge on Chronic Neuropathic Pain seeks to shed light on the molecular, cellular and circuit-level changes – or neuroplasticity – underlying the transition from acute to chronic pain. A key element of the program is to form research collaborations between experts on pain and experts on neuroplasticity to better understand how to successfully intervene at an early stage before the pain becomes chronic.
Across the Federal government, the Interagency Pain Research Coordinating Committee (IPRCC) has performed an analysis of the Federal pain research portfolio and identified the discovery of risk factors and mechanisms that predict and underlie the transition from acute to chronic pain as an important research area that needs further development. This report, as well as a pain research database, recently was released.
Mechanisms of Support
The Grand Challenge on Chronic Pain supports research through:
- Multi-PI R01 grants focused on understanding the maladaptive neurobiological changes that occur during the transition from acute to neuropathic pain.
- Competitive revisions that propose a collaborative, one year pilot study or a new specific aim associated with an active NIH grant. These initial studies are expected to lead to long term collaborations focused on the transition from acute to chronic neuropathic pain.
- NIH Pain Consortium
- Interagency Pain Research Coordinating Committee
- Dr. John Kusiak, Ph.D. National Institute of Dental and Craniofacial Research
|Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms & Interventions||Watkins, Linda||University of Colorado at Boulder||Multi-PI R01|
|VGF, Critical Role in the Transition from Acute to Chronic Pain||Vulchanova, Lyudmila||University of Minnesota Twin Cities||Multi-PI R01|
|Epigenetic and Genetic Contributors to Chronic Neuropathic Pain||Basbaum, Allan||University of California San Francisco||Multi-PI R01|
|TSC2 and ERK signaling in Motor-Dependent Regeneration and Neuropathic Pain||Cavalli, Valeria||Washington University St. Louis||Multi-PI R01|
|Epigenetic Mechanisms of Neuropathic Pain||Pan, Hui-Lin||University of Texas M.D. Anderson Cancer Center||Multi-PI R01|
|Hemichannels, Astrocytic Release, and Neuropathic Pain||Ji, Ru-Rong||Duke University||Multi-PI R01|
|Neuronal Subtype-Specific Plasticity in the Acute to Chronic Pain Transition||Ginty, David||Johns Hopkins University||Multi-PI R01|
|Cortico-striatal Plasticity in the Transition to Chronic Pain||Apkarian, Vania||Northwestern University||Multi-PI R01|
|Proteolysis of Myelin as a Source of Neuropathic Pain||Shubayev, Veronica||University of California San Diego||Multi-PI R01|
Previously Funded Projects
|Altered Sensibility Following Peripheral Nerve Damage||Woolf, Clifford||Children's Hospital Boston||Competitive Revision|
|Mechanisms Regulating Vesicular Axonal Transport Following Nerve Injury||Cavalli, Valeria||Washington University St. Louis||Competitive Revision|