In addition to supporting cross-cutting neuroscience activities like research training, workforce diversity, informatics and therapeutic development, Blueprint also funds research initiatives. Recently, Blueprint developed three Funding Opportunity Announcements (FOA) that will support research in FY2018:
The Dynamic Neuroimmune Interactions in the Transition from Normal CNS Function to Disorders (RFA-AA-18-07) R01 seeks to transform our understanding of the dynamic changes among multiple neuroimmune components and how they contribute to the onset and progression of central nervous system (CNS) disorders. Research supported by this FOA is expected to address temporal changes in multiple neuroimmune components, such as neurons, microglia, and astrocytes. Proposals that blend diverse expertise with innovative approaches that address these questions at the molecular, cellular, and circuitry levels were highly encouraged.
The Innovative Approaches or Technologies to Investigate Regional, Structural and Functional Heterogeneity of CNS Small Blood and Lymphatic Vessels (RFA-NS-18-003) R01 solicited research focused on the development of new technology and tools or novel mechanistic studies (or a combination of both) to image, profile and map central nervous system small blood and lymphatic vessels in health and disease across the lifespan. Additional goals of this research are to elucidate mechanisms underlying CNS small blood and lymphatic vessels structure and functional heterogeneity, differential susceptibility to injury, role in disease and repair processes, and responses to therapies.
The Development and Validation of Technologies for Rapid Isolation and Characterization of Extracellular Vesicles (EVs) of Central Nervous System Origin (RFA-MH-18-600) R21/R33 is a phased innovation award focused on technology development for robust and reproducible CNS-EV isolation methods. The primary goal of this initiative is to advance the current technologies, develop novel techniques and approaches, and standardize protocols to reliably and specifically isolate EVs of CNS origin from human biofluids, identify the cell type from which they were derived, and characterize their composition.